The good news is, you can't get lupus from going to Lupus. But you can get some really good down-home music and friendly vibes from the music playing in the general store.
I have only been there once, but sometimes you know it when you see it. And this place is a unique gem. Maybe it's not what you'd call "remodeled" or "passes city codes", but it has withstood the test of time good enough for me, and it seem to have an the kind of unpretentiousness where people there don't use big words or anything. My point is, it's not a place that is summed up in a yelp review very well. You sort of have to go there to see it.
Some history of Lupus. In 1993 there was like a 100 or 200 year flood, and the town was under 3 feet of water. They got some FEMA money to raise all the houses up like 10 feet. Literally. So you know you're in the right town when you see houses on stilts. Getting to Lupus is quite a drive, but I would say it's a good destination trip. The general store is the second to last building on the left as you head down main street towards the river. If you get to the railroad crossing, you've gone too far. The last building on the right is the city hall. The town has about 40 people in it.
Cover is $7 donation, and there is usually a jam afterwards, so bring you instrument if you so desire.
Oh yea, the store is also an antique place, and so if you need a player piano, or a kerosine lamp, this is the place for you.
Also, this place gets a spot on my best bathrooms list. Enough said.
Here's some of what other say about it:
http://www.robinsongs.com/1/post/2010/10/lupus-missouri.html
http://www.panoramio.com/photo/73916335
http://marciemcguire.wordpress.com/tag/lupus-general-store/ read more