This place is a gem. Set inside a beautifully restored old pharmacy, the atmosphere strikes a perfect balance between historic charm and lively energy. It feels warm, welcoming, and thoughtfully designed without trying too hard. Service was friendly and relaxed -- Jess took great care of us throughout the evening. There was a small hiccup with the chicken order initially, but it was corrected quickly and professionally, which says a lot about how the team operates under pressure. Expediting could have been a little tighter, but the recovery was handled well. The food was the real star. The tuna appetizer was outstanding, and the fried chicken was incredibly moist and flavorful -- even though the crust was darker than expected and looked overcooked at first glance, it turned out to be tender and delicious once we cut into it. Biscuits were excellent, mac and cheese was rich and satisfying, and the grits were perfectly done. Desserts -- the brownie and apple cobbler -- were absolutely amazing and a strong finish to the meal. The only minor disappointment was the honey mustard/honey barbecue sauce, which was thinner than expected and lacked that thicker, honey-forward texture you might anticipate. Overall, this was a fantastic dining experience. Great atmosphere, strong execution in the kitchen, and a team that clearly cares about taking care of their guests. Definitely a place worth returning to when in Wilmington. read more

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This one has been on my list for a while. Finally made it in for brunch. Highly recommend making a reservation as they are busy! Started with a variety of oysters. Mains- one sweet, one savory. Crab and shrimp quiche with side salad and French toast sub sweet potato home fries. Only scratched the surface as far as fresh local catch with the oysters. Note their menu will change depending on what they catch that day. Will come back for dinner! read more

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The food , the service , the ambiance all 10s across the board. We would definitely come back again. read more

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Perfection! This is the place to go for local, unique, sea to table fare. Tonight we thoroughly enjoyed the catch of the day, Trigger Fish. Mild, sweet with a texture like crab. The deviled eggs are a must! The Juicy Lucy oysters are perfectly salty and don't need horse radish or cocktail sauce. Go between 5-6 pm for half price oysters!). And the clam chowder was certainly different, not creamy. I loved it! The sourdough bread pudding was delicious, topped with soft serve. The serving is enough for three people. Everything about RX, from service to food, impeccable. We can't wait to go back for Lion Fish! read more

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This was an amazing meal with top notch service. I ended up having additional people that wanted to join my group for dinner and the staff was so accommodating. The location is not too large but as a former drug store location, it's adorable. Once seated, we were introduced to Jack who truly made our night. He was full of great suggestions and kept up with all of our drinks all night. I'm very glad I took his suggestions because every bite I had was delicious. The group has just about everything on the menu, but the standouts for me were the oysters Rockefeller, the collard greens, the dessert, and my cocktail (the Remedy). The others at the table agreed that everything was delicious, and we would absolutely return. I've got to get some chicken next time! read more

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Made a 5:00 reservation on Wednesday (half off oysters Wed-Fri, 5-6:00). Friendly and attentive service. Fresh farm/ocean to table entrees. Oysters (from their own NC farm) were amazing. Shrimp and Grits was fabulous, well balanced the light with loads of tender shrimp. Fried chicken was an experience where I could not stop. They were offering three fresh fish specials; tuna, tile, trigger. Eclectic decor, and love the linen napkins. Bathrooms could have been cleaner. Definitely coming back. read more

We made a reservation at Rx Chicken and Oysters about a week in advance, thinking it was a new spot. Would have never guessed it's actually been around for about 12 years and we've missed it this whole time. Walking in, was a real blast from the past for me. Last I was her ewas mid-90s, and it was the Halls Drug Store at that time. It's now an impressive, cozy, stylish restaurant with a really inviting vibe. The place was humming when we arrived. We started with the skillet cornbread. Oh my god, it was perfection. I could have easily just ordered 3 or 4 of these and called it a night. For miains we ordered the night's fish special and a chicken breast plate, and both were excellent. Perfectly cooked, full of flavor. The drinks too were awesome. Crafty cocktails and a solid lineup of local beers. Service was outstanding. Anthony was our server. He couldn't have been better. He knew the menu front to back, spoke about each dish with pride, and made us feel like regulars. The guy clearly cares about the place, and it shows. Foolish of me to call him "Matt" all night long. I don't know how I got Matt and Anthony mixed up. He never corrected me. Total class act. read more

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Stopped in Wilmington for the night and found Rx and everything about it was great! Everything we ordered was fantastic and the service was perfect. read more

Excellent choice for a menu if some like the seafood and others like the land food. My "Blueberry" BBQ Pork Chop pork with roasted potatoes and butter beans made my pallet satisfied! To top it off I had the 'cobbler of the day' which was peach. Next time I'll try the chicken. . The atmosphere was laid back and jammin with the music. And our server made great suggestions and very informative on the choices for the day. Half off glasses of wine on Tuesday. Glad we stumbled on this place in downtown historic Wilmington. read more

Rx Chicken & Oysters - Building mural on Castle Street. Free Parking all around. - Seafood Near Me - Wilmington, North Carolina

We had oysters which were very tasty. I had their salad which I enjoyed and the clam chowder soup which was tasty but different because it was in clear broth not creamy. The service was excellent and the ambiance is nice and casual.. read more

Rx Chicken & Oysters - Seafood Near Me - Wilmington, North Carolina

I have eaten here several times over the years and food and service are very good but the price has gone way too high for the for the portion that we received. $45 for 4 ounces of local caught fish is ridiculous read more

I love the concept of farm to table everything was good overall. Everything truly tasted like it was homemade. We had the salad, amazing, oysters, amazing, crab dip, pretty good, deviled eggs, delicious, chicken, left a lot to be desired for the price, sourdough bread pudding was the star of the show-absolutely incredible. Our server was great. I was a little upset because if you're a couple they won't let you sit at a booth which would've been much more comfortable for my very pregnant self. 3 booths sat empty until the last 10 minutes we were there and we only stayed as long as we did due to weather. read more

Rx Chicken & Oysters - Seafood Near Me - Wilmington, North Carolina

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What a fabulous dinner! Great food and service. Loved the artwork, the bar, the whole experience. Was celebrating a friend's birthday and she couldn't say enough about the freshness and preparation of the seafood. She had just moved back here from the Keys and she was surprised that she could get that quality and variety here. Sarah and her staff really made us feel welcome and it was a special experience! read more

Rx Chicken & Oysters - Happy customers! - Seafood Near Me - Wilmington, North Carolina

We've been wanting to try this establishment for some time, so we gave it a try the other day. While we would have liked to be seated in the main dining room or bar area, the only tables left were in the back room, even though we made a reservation. The room lacked ambiance and was a bit on the warm side since it was hot outside. Our server was nice and no complaints about the service at all. All staff seemed nice and attentive. We wanted a light meal, so we tried the Carolina Clam Chowder with a side of cornbread. What a disappointment! The soup was mainly a fatty broth with a few potatoes and clams that were not chewable. I had to spit them out, since they were like rubber. The chowder had bacon, no problem there, however it seemed like the bacon fat overtook the soup. The cornbread that seemed to be baked in a small iron skillet, was covered with grease - perhaps that's what kept it from sticking to the skillet, however it was not good. While we did not order items on the menu that they are known for, chicken and oysters, we were not hungry enough and besides, why would I pay $22 for fried chicken breast? It was bad enough that our bowl of broth with rubbery clams was $12 each. By the way, I've lived long enough to know the quality of the clams in chowder - not chewy or rubbery, but rather soft, chewable and pieces you can swallow! Sorry to say, we won't be back. read more

Incredible brunch, the quiche was the best I've ever had, waffle was fantastic eggs cooked to perfection and all 6 of us thought our meal was amazing.. great job we will all be back read more

Another great meal at Rx! Food and vibe are always the best! A must for locals and visitors! read more

Rx Chicken & Oysters - 1/2 fried chicken is a must! - Seafood Near Me - Wilmington, North Carolina

You can't get any more local or fresh than at RX! Seafood caught that morning and on your plate that evening, with locally sourced produce and meats, as well. Sarah and James have created a gem of a restaurant! It always has been and will always be one of our favorite spots in Wilmington. read more

1/2 price wine by the glass on tuesdays. Chicken was crispy on the outside and MOIST in the inside! They pressure cook and deep fry the chicken. Seasonings were insane on the skin you don't need the hot honey but please try it, it's great. The farmed oysters were the perfect size for me (as an app) and very briny which I love as a savory person. Absolutely will be returning. Service was wonderful, knowledgeable and got food and drinks very quickly. The restaurant is such a cool spot because it's a redone pharmacy. read more

Rx Chicken & Oysters - HALF BIRD mac and collards - Seafood Near Me - Wilmington, North Carolina

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this place blew me away! everything we had was excellent! service was fantastic! best crab dip i've ever had too. highly recommend!

Great place with wonderful ambience. We enjoyed a unique appetizer in marinated shrimp. Fried chicken entrée and fried oyster burger tasted great! Waiter was attentive and recommended tartar sauce over hot sauce for the fried oyster burger, which was a good recommendation. Collard greens side tasted good just a little strong. read more

Made an online reservation for Tuesday dinner the day before. It wasn't very busy while we were there from 6 to 7 PM. We started off with oysters. I tried the steamed Rx Lucy Beas based out of topsail sound and my partner enjoyed the Lucy Beas and Ana's Wild Harvest based out of Masonboro Sound. There were a total of five oyster options with Lucy Beas being the only one they farm and being the saltiest. The Lucy Beas oysters were very salty and were very good- the best part of the whole meal. The only condiment options for the oysters were hot sauce, butter, fresh lemon, fresh lime, horseradish, and cocktail sauce. For entrées, my partner got the large plate of fried oysters, which usually comes with slaw and fries. He was able to substitute a side salad for the fries. He enjoyed his dish. The slaw was red cabbage with a ginger flavor, which I wasn't into because of the ginger. The side salad was good, came with sliced radishes and carrots with the vinaigrette. They could've gone a little lighter on the vinaigrette, salad was saturated a bit too much. I tried the veggie burger, which came with Lusty Monk grainy mustard, bread and butter pickles, lettuce, and shoestring fries on a thick house made toasted sourdough bun. Only white potato fries were available, no sweet potato fries. The burger needed a sauce, otherwise, it was too dry and plain with just mustard. The veggie burger itself had good flavor though-ingredients included sprouted lentils, sweet potato, mushroom, rice. Bun was okay, very dense. The shoestring fries were good. For dessert had one of the hand pies with soft serve vanilla ice cream. Only apple flavor was available. It was deep-fried, crispy with a sweet, chopped apple filling, very good. Our waitress Hannah was kind and sweet. read more

Absolutely perfect Easter brunch today! Service was great, ambiance was perfect and the food was outstanding! We started off with the biscuits and jelly. They melted in your mouth. I had 2 raw oysters which were perfection. My son enjoyed his chicken and waffles and really liked the cheesy grits. My daughter had the French toast with bacon and an added egg. She ate every bite. My dad had the monte bestie and the sweet potato has browns. They were so delicious!! My mom had the wings (which I think are the best ones in NC) and a side salad. I had the crab and shrimp quiche which was undeniably wonderful. Pricing is so reasonable, too! read more

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Let me paint the picture: we made a 9:00 AM reservation for Father's Day brunch. We received a confirmation and guests from out of town arrived. We showed up with my elderly parents promptly at 9:00 AM, only to find the restaurant closed--as in, lights-off, doors-locked, not-opening-for-another-hour closed. When we finally spoke with the OWNER by phone, we were met with confusion, not accountability. Apparently, the restaurant doesn't even open until 10:00 AM. So why are they accepting and confirming 9:00 AM reservations? No one had an answer. No apology. No offer to make it right. Just an awkward brush-off and a clear message: "Not our problem." We were told to show up at opening time but RX could not guarantee a table or service. NO THANKS. VERY DISAPPOINTING attention to organization and TERRIBLE customer service. This place is either grossly disorganized or just doesn't care. Either way, it's not worth your time or trust. There are plenty of restaurants that know how clocks, calendars, and customer service work. Go to one of those instead. read more

Food....very flavorable Service .... Perfect Great knowledgeable waiter... Good seafood offers even in winter read more

I ordered shrimp and grits and husband ordered the red fish special. Fish and grits was good, but vegetables were super salty. My shrimp and grits didn't taste like it was seasoned at all. I had to take bites of shrimp and grab some of my husband's vegetable on his plate to balance taste. We informed our server to relay message so that kitchen can be mindful of seasonings because the food has potential to be good. Our server didn't look happy, but made sure he knows we are not mad at anyone, just sending constructive criticism so they know how to make things better. Maybe will try another time. Ambiance pretty chill and laid back. read more

Wonderful apps, entrees, desserts. Their fish special is always fresh & well prepared. I need to try the fried chicken which is their specialty but so far I've always ordered the specials. Chicken next time! read more

Great spot with a very local, fresh menu. Fried chicken & Mac and cheese were wonderful. Great deviled eggs too! So glad we stumbled upon it read more

Rx Chicken & Oysters - Seafood Near Me - Wilmington, North Carolina

The food at this establishment was amazing. I had oysters and the crab cake dish. It was out of this world. Very fresh ingredients. The service was on point and the lighting and comfortability was nothing short of perfection. 1/2 price oysters 5-6 to boot. read more

Love this place. The food is fantastic and fresh. The wonderful owners (James the chef and Sarah front of house) fish regularly and prepare the freshest seafood in town. Creative flavors with souther flair. Their Lucy Beas oysters are the best NC oysters I've had. Topnotch fried chicken and the best biscuits in the universe. Friendly service and a nice bar. read more

Rx Chicken and Oysters is a semi-formal restaurant, serving up fresh seafood. We ordered a fresh Oyster, the Peel & Eat Shrimp, Carolina Clam Chowder, and Shrimp & Grits. Our clear favorite for the evening were the Shrimp & Grits. The grits were creamy but light and were complemented by the perfect amount of fresh shrimp and sauce. We nearly cleaned the plate because that sauce was packed with so much flavor! The oysters and peel & eat shrimp were solid choices, and also very fresh. The Carolina Clam Chowder however was something we'll probably pass on since it was rather one-note and slightly too salty. An overall satisfying meal; if all we had that evening was the Shrimp & Grits, Rx would easily have been a 5 (no joke, great shrimp & grits!). read more

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I've had Rx on my list for several years & never got around to going before they closed & re-opened as "Rx Chicken & Oysters". I met a friend here after work last week for some wine & a few oysters. I got their Lucy b oysters & my friend got the other oysters, steamed. Mine were good, but a little saltier than what I'm used to. My friend enjoyed her oysters as well. I may return to try something else. I wasn't blown away, but a half a dozen oysters typically won't do that. read more

Rx Chicken & Oysters - Lucy B oysters - Seafood Near Me - Wilmington, North Carolina

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The local seafood (we had the mussels and oysters) were perfectly cooked and fresh. The lobster hush puppies were divine with a little salt on the batter. Cool atmosphere and goo read more

We'd been there before and the atmosphere was pretty good as well as the food. Today, not so much. We were seated in the patio area which is nice for conversation...but we felt somewhat out of sight out of mind by our waiter. The deviled appetizer was probably the best part. The menu item I selected was a monte christo, but what arrived was a piece of dense toast with sparse salty ham, melted cheddar cheese and a runny egg (after I requested an egg over hard) coupled with sweet potato fries pieces that looked like they came out of a frozen bag. The waiter tried to compensate by bringing two small cinnamon rolls that were doughy and under cooked, but I ate mine because I was craving something sweet (hence, why I ordered a monte christo in the first place). The Bloody Marys tasted ok, but it was the sadest attempt I'd ever seen at garnish...no celery, bacon or anything remotely imaginary...just a sad thin slice of wimpy pickle with an equally sad little olive...that's it. Let's just say I was glad we had a gift card for a $65 brunch that left us disappointed. Don't think we'll be running back any time soon, which is sad, because I really liked the owner I met the first time we went and the fact that they'd taken such great care in preserving the persona and history of Halls Drug Store. read more

Wow! Great meal, great ambiance and great service (Nick knows his stuff). First time there. We had the Lucy Bea oysters & cornbread for the table. Shared a half chicken, biscuits & mashed sweet potatoes. Am sorry we didn't get dessert but will next time, for sure. Cool atmosphere with delicious food. Will be back. read more

I've been melting with anticipation for Rx to reopen. Thrilled with how they have taken the time to diligently craft an amazing menu and expertise. We enjoyed their 2 farm oysters one was Lucy and I don't remember the name of the other. Both delicious and flavorful, each unique. HIGHLY recommend! Then roasted oysters and fried chicken (wing, thigh, leg). Perfectly crispy and juicy. Side of coleslaw was unique, almost kimchi-esque. Crunchy and vinegar, not spicy or sweet had their veggie taco, cause they do it with a combo of veggies rather than typical black bean or pho meat. It was dense and flavorful. Already made a reservation to come back to try their pork belly and those oysters again! read more

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I was privileged to be the guest of my favorite Landscape Architects for dinner here last night. I got a to try the Oyster's Rockefeller, pig's ears and for my entree, the Shrimp and Grits. It was all very good. Waitress was Gabby, who was very friendly and gave great service. The place is nice inside, very eclectic, the old building used to be a pharmacy. read more

Enjoyed the entire experience. Nice vibe, liked the sound deadening panels that kept it chill. Some high ceiling older restaurants have a high noise level here you could have nice conversations Staff super. Attentive but not intrusive. Great menu, a mixture or small plates and mains. Had the fried chicken and it was fabulous. Tasty crust and juicy chicken. Everyone has their fav Mac& cheese; this was a classic and great. My companion had clams ceviche and roasted oysters. Both excellent and fresh and flavorful. Shout out to the Carolina Chowder. Nice bar and exciting signature cocktails. Good beer selection. The was our first of hopefully many visits. Another Castle Street gem read more

This place is the perfect neighborhood restaurant that's not necessarily in your neighborhood, but it has that same vibe. It's comfortable and relaxed. The food was well prepared and service was terrific. Looking forward to our next visit. read more

Rx is a must. Our server Rick was one of the best. The food is amazing. Fresh and delicious. The wine list was so interesting. Can't wait to return and try another bottle. The oysters taste as if just out of the sea ( which they are). It's a menu everyone can find something. 5 stars all the way. read more

Had a great experience at the RX. The food was delicious and well presented, the service was superior and the atmosphere top notch. It had a locals feel to it but as an out of towner I felt welcome. It was great to find fried chicken done right, and not drenched in sprices. read more